Superantigen Jesse Russell

ISBN: 9785512208267

Published: March 26th 2012

Paperback

138 pages


Description

Superantigen  by  Jesse Russell

Superantigen by Jesse Russell
March 26th 2012 | Paperback | PDF, EPUB, FB2, DjVu, AUDIO, mp3, ZIP | 138 pages | ISBN: 9785512208267 | 6.45 Mb

High Quality Content by WIKIPEDIA articles! Superantigens (SAgs) are a class of antigens which cause non-specific activation of T-cells resulting in oligoclonal T cell activation and massive cytokine release. SAgs can be produced by pathogenicMoreHigh Quality Content by WIKIPEDIA articles! Superantigens (SAgs) are a class of antigens which cause non-specific activation of T-cells resulting in oligoclonal T cell activation and massive cytokine release. SAgs can be produced by pathogenic microbes (including viruses, mycoplasma, and bacteria) as a defense mechanism against the immune system.

Compared to a normal antigen-induced T-cell response where .001-.0001% of the bodys T-cells are activated, these SAgs are capable of activating up to 20% of the bodys T-cells. Furthermore, Anti-CD3 and Anti-CD28 Antibodies (CD28-SuperMAB) have also shown to be highly potent superantigens (and can activate up to 100% of T cells).



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